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This high background signal is a significant obstacle for diagnosing primary hepatocellular carcinoma, potentially limiting the utility to extrahepatic metastases unless structural modifications alter its excretion pathway (129)

Although no causal role has been established, activin A is a pleiotropic cytokine known to influence immune regulation and is altered in various autoimmune and inflammatory diseases (524)

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Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

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