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One of the main features of ferroptosis is impaired mitochondrial structure, but it is not easy to observe changes in mitochondria

284 MAT2A Methylthioadenosine phosphorylase (MTAP)-deficient tumors account for ~15% of solid tumors, including ~15% of NSCLC, 28% of esophageal cancer, 26% of bladder cancer, and 10% of esophagogastric cancer

[2] Copper also appears to be vital in iron metabolism and embryonic development, potentially essential for most metabolic reactions that occur in fetal development, oxygenation, and other biological processes

10.1016/j.cosust.2013.09.002 [DOI] [Google Scholar] McClements, D