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Chu and Pratic, 2011)

Studies suggest that dual options may have a greater impact on reducing weight in individuals with obesity or overweight, surpassing the effects of weight loss injections

Potential Benefits of a Modified Approach (for Select Individuals) For a carefully selected group of individuals, under stringent medical supervision, a modified dosing schedule might offer several potential advantages: Enhanced Side Effect Management One of the most compelling reasons a healthcare provider might consider a split dose is to alleviate the intensity of gastrointestinal side effects, such as nausea, vomiting, or constipation

In: ICH E9 (R1) addendum on estimands and sensitivity analysis in clinical trials to the guideline on statistical principles for clinical trials

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