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GLP-1RAs can exert not only anti-inflammatory effects in the endothelium, but also anti-apoptotic effects aimed at maintaining endothelial homeostasis

Two large 72-week clinical trials that evaluated terzepatide in individuals who were overweight or obese found that by the end of the study, people who also dieted and exercised reported statistically significant weight loss compared to those who took the placebo

For semaglutide 1 , 74.8%, 54.8%, and 34.8% achieved those, while for tirzepatide [4] it was 90.1%, 78.2% and 62.9%