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2015 Jun;29(6):2268-80
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The results showed a consistent advantage for the combination, and that advantage became more pronounced at higher weight loss thresholds, precisely where GLP-1 therapy tends to be most clinically meaningful: At a 20% weight loss threshold, 45% of women in the combination group achieved this level of loss, compared to 24% in the GLP-1 alone group
Longer-term clinical studies and real-world evidence will be essential to better characterize the safety profile of cagrilintide-semaglutide, particularly regarding uncommon adverse events, treatment persistence, and its effects on body composition and bone health
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