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The primary mediator of this system is locally produced hypo-glycosylated erythropoietin (EPO) that acts through a distinct receptor isoform, the innate repair receptor (IRR), which is a combination of EPO receptor and common receptor subunits (9)

In addition to RSS , there is also the possibility of polysulfide (RS(S) n S ) formation, but their amounts and significance in biological systems remain unclear 43

Since leaky gut symptoms overlap heavily with other GI diseases and sometimes leaky gut is a symptom of a larger GI disease ruling out other problems should generally be your first step

The risks are substantial and multi-layered

The soothing efficacy is also backed up by multiple in-vivo studies