comparison of semaglutide and tirzepatide Vs For Weight Loss (2026): Which Works Better? tirzepatide vs semaglutide comparison effectiveness

As you become more comfortable with the process, your focus can shift from the mechanics of the injection to the lifestyle changes that drive long-term success

Your clinician will titrate carefully and adjust if needed

2022;54(1):e14242

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Trial design: 751 adults with obesity (BMI 30, or 27 with at least one comorbidity) No type 2 diabetes 72-week follow-up Tirzepatide 10mg or 15mg vs Semaglutide 2.4mg Results at 72 weeks: When looking at tirzepatide weight loss results from SURMOUNT-5 alongside semaglutide weight loss results from the STEP trials, the gap is consistent and statistically significant across every subgroup sex, age, baseline BMI, and presence of metabolic comorbidities