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We picked up the pose with the lowest G free energy binding affinity value, in kcal/mol, to be elected as the most representative SLC25A45-TML docking complex

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Although NAC is often used in the clinic to restore hepatocellular GSH levels to protect against APAP hepatotoxicity, in the context of mitochondrial cholesterol accumulation, which impairs the transport of cytosol GSH into mitochondria, the use of NAC may be inefficient to specifically replenish mGSH stores, requiring the use of permeable GSH prodrugs such as GSH ethyl ester (GSHEE)