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The use of surfactants can enhance drug delivery across the BBB by increasing the fluidity of the endothelial cell membrane [82]

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They have been shown to inhibit the production of IL-1, 2 and 6 and the phosphorylation of IkB kinase (IkappaB) (254), and thus the NF-kB signalling pathway

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Subsequently, structural modelling and refinement were performed using COOT and REFMAC5 33,34