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Food and Drug Administration (FDA) Consumer Updates on GLP-1 Receptor Agonist Efficacy, Approved Semaglutide High-Dose Guidance, and Public Safety Alerts (USA Gov)

Clinical studies, including the STEP 1 extension trial, have demonstrated that patients who discontinue GLP-1 receptor agonists often regain a significant portion of lost weightsometimes two-thirds or morewithin one year of stopping treatment

Stopping semaglutide can lead to a range of effects, including an increase in weight

This is why some clinicians advocate for faster dose escalation in higher-weight individuals and slower escalation for those closer to goal weight

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