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Low levels of glutathione send messages to trigger apoptosis or cell death

2.3.6 Phagocytosis Phagocytic activity of peripheral blood mononuclear cells (PBMC) and polymorphonuclear neutrophils (PMN) was measured immediately after sampling by flow cytometry in heparinized blood using the reagent kit PHAGOTEST (Glycotope Biotechnology, Heidelberg, Germany)

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Current mainstay interventions, including intensive lifestyle modification and bariatric surgery, demonstrate suboptimal and often unsustainable long-term efficacy in this genetically defined population, highlighting a critical unmet need for effective, accessible, and durable pharmacological strategies