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In the FF, melatonin eliminates free radicals and stimulates antioxidant enzymes in addition to promote sex steroid hormone production by granulosa cells which support follicle development leading to ovulation (3)
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For the mediation analysis on the histology endpoints evaluating change in body weight as mediator, data were based on complete-case on-treatment measurements to evaluate the mechanistic action of semaglutide in MASH (hence, data outside the on-treatment observation period were excluded)
Sciacca, P
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