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Carnitine chemical structure was established in 1927 and its function was related to long-chain fatty oxidation in liver and heart in 1959 [2,3]

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The pineal gland is located in the very center of the brain and plays a vital role in all body systems

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207,208 Moreover, based on findings from mouse models, obesity reduced the number and function of CD4 + T cells in the TME of CRC, leading to a compromised antitumor response of both CD4 + and CD8 + T cells and ultimately accelerating disease progression