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Diabetic retinopathy: Rapid improvement in blood glucose control can sometimes cause temporary worsening of diabetic retinopathy

Individuals with genetic single nucleotide polymorphisms (SNPs) resulting in hyperactive IIS may be at special risk for the development of age-related diseases, predominantly when their high intrinsic IIS is superposed by exaggerated IIS of Western diet

This distinction is particularly relevant for clinical practice, as REWIND demonstrated benefits in patients at moderate cardiovascular risk without previous events

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Consider physical activity level, health status, and protein quality