soul trial oral semaglutide cardiovascular outcomes 2025 New in the May 29, 2025, issue of NEJM: Sotatercept in Pulmonary Arterial Hypertension (ZENITH phase 3 trial) https://nej.md/4iYkLbj and (SOUL trial) https://nej.md/4hHII5M Upadacitinib for Giant-Cell Arteritis ADA 2025: Oral Semaglutide Demonstrates

This suggests the weight loss wasnt from making the mice sick or suppressing appetite, but from genuinely changing their metabolism to burn more energy

Why these two get studied together The short answer is that the preclinical literature on each peptide individually points at overlapping but distinct elements of the wound-repair toolkit: BPC-157 has been associated with angiogenesis and growth-factor signaling, while thymosin beta-4 fragments have been associated with cell migration

BPC, by the way, stands for Body Protection Compound

Claudia Oliviera 9

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