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Furthermore, the GLP-1R G-protein-biased agonist dosed at 1 or 10 g kg 1 significantly decreased ad libitum -fed blood glucose levels when compared with vehicle control whereas Ex4 showed efficacy only at the highest dose tested (Fig
[4] [5] The standard of care remains disease-modifying antirheumatic drugs (DMARDs), including conventional synthetic DMARDs like methotrexate as first-line therapy, with escalation to biological DMARDs or targeted synthetic DMARDs if disease activity remains inadequately controlled, following a treat-to-target approach
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