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Two phase 2 trials are currently active but not recruiting: NCT04305002 evaluates weekly exenatide (2 mg) with disease progression measured by FDG-PET and MDS-UPDRS III, while NCT04269642 is investigating PT320, a sustained-release formulation of exenatide (2.0 or 2.5 mg biweekly), in patients with early PD

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Better sleep directly supports sexual function through several mechanisms

In these clinical trials, peptides stimulating growth hormone release appeared to deliver some action in two ways possibly either via stimulating the pituitary gland to release growth hormones, or possibly acting on the arcuate nucleus of the hypothalamus