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Expression of -glutamyltransferase in cancer cells and its significance in drug resistance

On one hand, gut dysbiosis facilitates ferroptosis by affecting iron metabolic pathways, like blocking the synthesis and release of hepatic hepcidin and expression of the iron transporter FPN1 to inhibit iron efflux and causing systemic and local iron overload in joints, thus leading to ferroptosis in OA chondrocytes

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However, prior clinical and animal studies have focused on studying chronic liver injuries caused by long-term use (48 weeks) of OXA-based chemotherapy

Delicate care for the treated area is also needed during the recovery period for the treatment to be effective