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Kennedy.) They may be longer-lasting than natural versions, or raise concentrations beyond what would naturally occur in the body

Microbubbles can also be loaded with therapeutics (e.g., chemotherapeutics, recombinant proteins, genetic material, or whole cells) and/or imaging agents 91,92,104,105,106,107 which are released into the targeted area upon applying ultrasound

Thats the crux of how these medications may help with cravings.

doi:10.1080/15216540310001659029

Since weight loss medications work systemically through receptor activation rather than requiring gallbladder function, the absence of this organ does not fundamentally impair their therapeutic mechanism