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They decided that rather than accepting the fact that smoking caused disease, they would create an independent research organization, the Tobacco Industry Research Committee, to fund research to get to the bottom of the smoking and health controversy. They announced the creation of the TIRC in full page ads in newspapers and magazines all over the country assuring smokers and policymakers that the companies accept an interest in peoples health as a basic responsibility, paramount to every other consideration in our business. The tobacco companies did no such thing

For cannabis and nicotine, the discrepancy in the sensitivity analysis can be explained in the chosen endpoints (no dose response data on mortality in humans were identifiable in the literature)

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