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It was reported that the upregulation of miR-21-3p or miR-27b-3p in CSE-treated Beas-2B-derived exosomes could not only induce macrophages RAW264.7 to express CD86, CD80, CD163 and CD206, but also promote them to produce TNF-, IL-6, inducible nitric oxide synthase (iNOS), IL-10, Arginase (Arg)-1 and transforming growth factor-beta (TGF-), suggesting their ability to polarize the macrophages into M1 phenotype and M2 phenotype simultaneously [83]
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Here are some of the most popular expressions used to provide commentary on various experiences: a gas - having a fun time, often used to describe lively situations bad - awesome, used paradoxically to mean something very good or impressive beat feet - leave quickly, often in a hurry to escape an unpleasant situation blast - a good time, a loud party, typically describing a lively and fun event boss - fantastic, used to describe something exceptionally good bug out - to leave, especially in a hurry or suddenly bummer - an unpleasant experience catch some rays - get out in the sun, typically for sunbathing or relaxing outdoors cut out - leave the area quickly downer - an unpleasant experience (or person), often bringing down the mood drag - something (or someone) that's boring fab - fabulous far out - awesome, expressing amazement or approval flake off - leave, especially casually or without a formal goodbye flower power - the peaceful protest movement of the 60s counterculture, emphasizing non-violence and love freak out - get excited and lose control, often in response to overwhelming emotions or situations gimme some skin - to ask someone to slap or shake your hand in agreement hairy - difficult or out of control, used to describe challenging situations hang loose - take it very easy, a laid-back approach to life hang tough - to stick with something difficult, showing resilience or determination heavy - a serious or intense subject, often requiring thoughtful consideration jam - play music together, especially in an impromptu or informal setting jazzed - excited, feeling enthusiastic or thrilled about something kicks - something done for pleasure, typically fun or recreational activities laid back - relaxed, having a calm and easy-going attitude neato - awesome, expressing enthusiasm or approval no sweat - no problem, indicating something is easy and not a cause for concern on the make - looking for a date, actively seeking romantic connections outta sight - awesome, expressing a high level of approval or amazement pig out - overeat
