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Specifically, occasional smokers (i.e., those who smoked less than one day per week) smoked approximately 13 times more cigarettes than non-smokers, while smokers who smoked almost every day of the week smoked approximately 45 times more cigarettes than non-smokers

For example, tissue damage associated with increased exposure to carcinogenic compounds in smoke may cause elevated concentrations of neutrophils, and activate intracellular signaling cascades which in turn stimulate inflammatory gene activation [18]

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So naturally, Gaga smoked a big ol' spliff while onstage